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How B12 relates to energy production: Facilitates the metabolism of fats and carbohydrates into usable energy Supports red blood cell production, which carries oxygen to tissues Maintains nervous system function, affecting cognitive performance and mood Acts as a cofactor in metabolic pathways that contribute to energy production It is important to note that whilst B12 is essential for energy metabolism, there is no official link between B12 supplementation and increased energy levels in individuals with normal B12 status

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Studied in models involving nicotinamide N-methyltransferase signaling, methylation-linked metabolism, and metabolic pathway regulation

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The absence of safety data in these populations should inform clinical decision-making and prescribing practices